中央純水系統以管線方式做為超純水系統的供給水時，會有什麼樣不良結果？(菌膜孳生與TOC偏高問題)
實驗設施中，若在某個固定地點進行純水純化，再利用管線將數個用水點加以連結以供應純水，這種系統就稱為中央純水系統。
一般的純水系統（小型純水系統）與中央純水系統的最大差異在於，純水的存放位置不同，也就是圖１中的黑色小方塊。小型純水系統會受到適當的維護以保持良好的水質，例如在貯桶中保存時，會利用紫外線照射來抑制微生物的污染。相反的，滯留於配管中的純水無可避免的會有細菌的孳生。在除過氯的純水中，微生物很容易繁殖，尤其較長的管線中微生物則會附著在管壁上形成菌膜 (Biofilm)，而一旦形成頑強的菌膜，即使以化學試劑或是熱水來清洗，只會對菌膜表面的細菌有效，在處理過後，菌膜深層的細菌能很快地使菌膜回復到處理前狀態，所以除菌效果很差。
圖２、３ 為實際使用中央超純水系統的設施，對各個研究室的超純水水質（有機物含量與生菌數）所監測的結果。
中央純水系統雖然與小型純水系統都使用相同的純水原理來純化，各研究室的水質仍呈現不同變化，尤其在夏天的生菌數很高。這表示，夏天由於水溫高使微生物繁殖快速，進而產生菌膜。而微生物繁殖所產生的代謝物會造成有機物質的污染。因此，中央純水系統雖然以相同的純化方法生產純水，但由於配管路徑、不同的取水地點與時間，所取得純水水質卻有很大的不同。我們經常可以發現，中央純水系統雖然可在純水製造處執行水質管理，但卻無法針對各個使用點管理，並且使用者通常對於水質劣化也不注意，所以造成實驗結果不佳卻又找不到原因的窘境。此外，純水中的微生物檢測是以懸浮生菌數為指標，雖然一旦有微生物被檢測出來，卻無法判斷菌膜最可能存在的地點，所以必須要進行系統全面的處理。管線的微生物管理必須進行衛生級配管，且每週一次定期熱殺菌處理。如此頻繁的維護工作會花費相當多的經費，也會有無水可用的停水期間，使微生物管理經常無法做得非常完整。
由於加氯的自來水具有最佳微生物管控能力，所以最好的方法是，以自來水作為供給水，而在各個使用點裝設純水系統，使用者在使用純水時應可先確認水質，並整合實驗室內部共同進行純水系統維護。
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